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ea0029p285 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Arafat A. , Rudovich N. , Weickert M. , Adamidou A. , Spranger J. , Birkenfeld A. , Mohlig M. , Pfeiffer A.

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients with the metabolic syndrome, hyperglucagonemia is a common feature, besides hypertension and hyperinsulinemia. Our aim was to evaluate the impact of glucagon on proANP and the possible mechanisms underlying this effect.<p clas...

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ea0037gp.17.03 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Insulin-induced hypoglycaemia decreases IGF1 bioactivity in humans: a missing link to increased mortality in diabetic patients?

Sarem Zeinab , Assefa Biruhalem , Weickert Martin O , Adamidou Aikatarini , Frystyk Jan , Mohlig Matthias , Lieske Stefanie , Birkenfeld Andreas L , Pfeiffer A.F.H , Spranger Joachim , Arafat Ayman M

Background: The mechanisms underlying the association between severe hypoglycaemia and increased cardiovascular mortality among patients with diabetes mellitus are not fully understood. Our aim was to evaluate changes in GH/IGF1 axis during insulin-induced hypoglycaemia, as a possible link.Methods: Twenty-five healthy subjects, 12 obese participants (OP; 6/ 6; 34.4±1.7 kg/m2), and 13 healthy lean participants (LP; 6/ 7; 21.7±0.6 kg/m...

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Endocrine Abstracts

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Insulin-induced hypoglycaemia decreases IGF1 bioactivity in humans: a missing link to increased mortality in diabetic patients?

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